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Living well with menopauseResearch on equol

There has been a variety of studies on how equol works, and its effects on the human body. More recently, it has been shown to have a broad effect on maintaining the overall health in women over 40, such as ameliorating the effects of menopause and maintaining the health of bones, the skin, and blood vessels.

  1. 1A research study on the relationship between soy isoflavones, equol, and menopausal symptoms in Japanese women.
    Uchiyama S, Ueno T, Masaki K, Shimizu S, Aso T, & Shirota T (2007)
    The cross-sectional study of the relationship between soy isoflavones, equol and the menopausal symptoms in Japanese women [in Japanese].
    J Jpn Menopause Soc 15, 28-37
  2. 2Isolation and identification of a new equol-producing lactic acid bacterium from human feces.
    Uchiyama S, Ueno T, & Suzuki T (2007)
    Identification of a newly isolated equol-producing lactic acid bacterium from the human feces [in Japanese].
    J Intest Microbiol 21, 217-220
  3. 3Detection of Lactococcus garvieae from food, and its potential residence in the human intestine.
    Uchiyama S, Kimura H, Ueno T, Suzuki T, Tadano K & Ishimi Y (2007)
    Detection of Lactococcus garvieae in foods and its existence in the human intestine [in Japanese].
    J Intest Microbiol 21, 221-225
  4. 4The role of equol in the effects of isoflavones on the bone and fat in postmenopausal Japanese women: a double-blind, randomized, and controlled trial.
    Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M & Ishimi Y (2007)
    The possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women:
    a double-blind, randomized, controlled trial.
    Menopause 14, 866-874
  5. 5Acute and subchronic toxicity, and genotoxicity of SE5-OH, an equol-rich food product produced by Lactococcus garvieae.
    Yee S, Burdock GA, Kurata Y, Enomoto Y, Narumi K, Hamada S, Itoh T, Shimomura Y & Ueno T (2008)
    Acute and subchronic toxicity and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieae.
    Food and Chemical Toxicology 46, 2713-2720
  6. 6Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
    Matulka RA, Matsuura I, Uesugi T, Ueno T & Burdock GA (2009)
    Developmental and reproductive effects of SE5-OH: an equol rich soy-based ingredient.
    J Toxicol ID: 307618, [Epub 15 December 2008].
  7. 7Blood kinetics of S-(-)equol, after the administration of SE5-OH pill to healthy, post-menopausal women.
    Matulka RA, Matsuura I, Uesugi T, Ueno T & Burdock GA (2009)
    Developmental and reproductive effects of SE5-OH: an equol rich soy-based ingredient.
    J Toxicol ID: 307618, [Epub 15 December 2008].
  8. 8Equol improves menopausal symptoms in Japanese women.
    Aso T (2010)
    Equol improves menopausal symptoms in Japanese women.
    J Nutr 140, 1386S-1389S.
  9. 9Natural S-equol decreases bone resorption in postmenopausal, non-equol producing Japanese women: a pilot randomized, placebo-controlled trial.
    Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M & Ishimi Y (2011)
    Natural S-equol decreases bone resorption in postmenopausal, non-equol producing Japanese women: a pilot randomized, placebo-controlled trial.
    Menopause 18, 563-574.
  10. 10Effects of S-equol and natural S-equal supplement (SE5-OH) on the growth of MCF-7 cells in vitro, and in ovariectomized athymic mice.
    Onoda A, Ueno T, Uchiyama S, Hayashi S, Kato K & Wake N (2011)
    Effects of S-equol and natural S-equol supplement (SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into
    ovariectomized athymic mice.
    Food Chem Toxicol 49, 2279-2284.
  11. 11Natural S-equol decreases bone resorption in postmenopausal, non-equol producing Japanese women: a pilot randomized, placebo-controlled trial.
    Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M & Ishimi Y (2011)
    Natural S-equol decreases bone resorption in postmenopausal, non-equol producing Japanese women: a pilot randomized, placebo-controlled trial.
    Menopause 18, 563-574.
  12. 12A natural S-(-)equol supplement alleviates hot flashes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women.
    Aso T, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H & Ohta H (2012)
    A natural S-(-)equol supplement alleviates hot flashes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women.
    J Womens Health (Larchmt) 21, 92-100.
  13. 13A pilot study on the effects of S-equol on the frequency of menopausal hot flashes and other menopausal symptoms, compared to soy isoflavones.
    Jenks B, Iwashita S, Nakagawa Y, Regrand K, Lee J, Carson W, Ueno T & Uchiyama S (2012)
    A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency.
    J Womens Health (Larchmt) 21, 674-682
  14. 14The effects of natural S-equol supplements on obesity and metabolic syndrome in the Japanese, based on sex and equol production.
    Usui T, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A, Shimatsu A, Inaguma A, Ueno T, Uchiyama S & Satoh-Asahara N (2013)
    Effects of natural S-equol supplements on obesity and metabolic syndrome in the Japanese, based on sex and equol production.
    Clin Endocrinology 78, 365-372
  15. 15A discovery of S-equol in stinky tofu, a traditional Taiwanese fermented soy bean product.
    AbiruY, Kumemura M, Ueno T, Uchiyama S, & Masaki K (2012)
    Discovery of an S-equol rich food stinky tofu, a traditional fermented soy product in Taiwan.
    Int J Food Sci Nutr 63(8), 964-970
  16. 16A distribution of 24-hour urinary equol excretion, as an indicator of the physiological range for healthy Japanese equol excretors.
    Ueno T, Abiru Y, Uchiyama S, Ishimi Y (2014)
    Distribution of 24-h urinary equol excretion as an indicator of the physiological range in healthy Japanese equol excretors.
    J Functional Foods 7, 129-135