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InnerSignal

Unique Skin Care System Based on Otsuka’s Concern for Skin Health

The key to the InnerSignal skin care system is Energy Signal AMP*, a medicated active ingredient that promotes cellular turnover. It works by boosting the energy metabolism of skin cells that have been negatively impacted by factors such as lifestyle habits and aging, and by encouraging skin rejuvenation.

  • Adenosine monophosphate OT (AMP): This ingredient is found in InnerSignal Rejuvenate Extract, Lotion, Milk, Cream, Mask, Extract Dual, and Clear Up Eyes.

Product Line-up

You can find detailed product information below.

Basic skin care products containing Energy Signal AMPAMP Skin Care System

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Quasi-drug InnerSignal Rejuvenate Extract

InnerSignal Rejuvenate Extract

Quasi-drug

This extract quickly delivers Energy Signal AMP, InnerSignal's unique active medical ingredient, to the skin's mother cells. This increases their energy metabolism and promotes cell turnover, for newer and clearer skin.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredients Disodium adenosine monophosphate OT, 2K glycyrrhizic acid
Other ingredients Concentrated glycerin, squalane, polyglyceryl isostearate, acrylic acid - methacrylic acid alkyl copolymer, sodium isostearoyl lactate, polyglyceryl stearate, anhydrous (dehydrated) ethanol, paraben, sodium hydroxide, purified water
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Quasi-drug InnerSignal Rejuvenate Lotion

InnerSignal Rejuvenate Lotion

Quasi-drug

This lotion contains nine types of moisturizing ingredients including hyaluronic acid, and penetrating glucose, as well as Energy Signal AMP, the medicated active ingredient. Along with accentuating the effect of the AMP, this lotion leaves every inch of the outer epidermis full of moisture.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredient Disodium adenosine monophosphate OT
Other ingredients Rose water, concentrated glycerin, POE methylglucoside, PEG 1500 (polyethylene glycol 1500), glycosyl trehalose and hydrogenated starch hydrolysate mixture solution, POE/POP decyltetradecyl ether, polyphosphorylcholine glycol acrylate, xanthan gum, sodium hyaluronate 2, glucose, vegetable squalane, hydrogenated soy phospholipid, polyglyceryl laurate, pentylene glycol, vitamin E, anhydrous (dehydrated) ethanol, paraben, DL-malic acid, sodium hydroxide, purified water
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Quasi-drug InnerSignal Rejuvenate Milk G

InnerSignal Rejuvenate Milk G

Quasi-drug

This product contains the medicated active ingredient Energy Signal AMP as well as penetrating glucose and natural ceramide as moisturizing ingredients. It adequately replenishes AMP in the skin, and leaves it plump and supple.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredient Disodium adenosine monophosphate OT
Other ingredients Concentrated glycerin, alpha-olefin oligomer, anhydrous (dehydrated) ethanol, rose water, polyglyceryl isostearate, acrylic acid -methacrylic acid alkyl copolymer, sodium isostearoyl lactate, polyglyceryl stearate, BG (butylene glycol), decaglyceryl myristate, ceramide 2, cholesterol, phenoxyethanol, vitamin E, glucose, vegetable squalane, hydrogenated soy phospholipid, polyglyceryl laurate, pentylene glycol, paraben, sodium hydroxide, purified water
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Quasi-drug InnerSignal Rejuvenate Cream G

InnerSignal Rejuvenate Cream G

Quasi-drug

This product contains not only the medicated active ingredient Energy Signal AMP, but also penetrating glucose, batyl alcohol and hydrogenated soybean phospholipids which have a moisturizing function. It supplies AMP to the cells, and leaves skin looking smooth and radiant.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredient Disodium adenosine monophosphate OT
Other ingredients Concentrated glycerin, squalane, capryl/capric triglyceride, anhydrous (dehydrated) ethanol, rose water, cetyl palmitate, decaglyceryl myristate, behenyl alcohol, dimethicone, glyceryl stearate SE, batyl alcohol, sodium isostearoyl lactate, acrylic acid -methacrylic acid alkyl copolymer, glucose, hydrogenated soy phospholipid, vegetable squalane, wild rose oil, polyglyceryl laurate, pentylene glycol, vitamin E, paraben, sodium hydroxide, purified water
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Quasi-drug InnerSignal Rejuvenate Clear Up Mask

InnerSignal Rejuvenate Clear Up Mask

(Initial product name: InnerSignal Rejuvenate Clear Up Mask F, InnerSignal Rejuvenate Clear Up Mask ND)

Quasi-drug

This mask provides all-at-once care not just for the face, but also for the neck and chest, where obvious signs of age can be seen. It provides an adequate replenishment of Energy Signal AMP to the areas you care about most. Use once a week as part of your home beauty routine.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredient Disodium adenosine monophosphate OT
Other ingredients DPG (dipropylene glycol), squalane, concentrated glycerin, polyglyceryl isostearate, acrylic acid -methacrylic acid alkyl copolymer, sodium isostearoyl lactate, polyglyceryl stearate, paraben, sodium hydroxide, purified water
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Quasi-drug InnerSignal Rejuvenate Extract Dual

InnerSignal Rejuvenate Extract Dual

Quasi-drug

This soft and supple sheet-type serum is for your cheeks and the area around your eyes, which are often a concern. It contains Energy Signal AMP as well as water-soluble moisturizers such as hyaluronic acid, for intensive care of both dark spot and dryness concerns.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredient Disodium adenosine monophosphate OT
Other ingredients Concentrated glycerin, glycosyl trehalose and hydrogenated starch hydrolysate mixture solution, powdered agar, BG (butylene glycol), betaine, sodium dextran sulfate, xanthan gum, locust bean gum, sodium hyaluronate 2, paraben, citric acid, sodium hydroxide, purified water
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Quasi-drug InnerSignal Rejuvenate Clear Up Eyes

InnerSignal Rejuvenate Clear Up Eyes

(Initial product name: InnerSignal Medicated Cream)

Quasi-drug

This product is for multiple problems under the eyes, which are always a concern. The medicated active ingredient, Energy Signal AMP, increases the energy metabolism of skin cells, helping to promote eyes that are firm, clear and fresh. At the same time, it supplies a moisturizing effect from multiple ingredients such as hydrogenated soybean phospholipids, batyl alcohol, and glucosyl hesperidin, which strengthen the skin's barrier and moisturizing functions.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Active ingredient Disodium adenosine monophosphate OT
Other ingredients Alpha-olefin oligomer, concentrated glycerin, capryl/capric triglyceride, behenyl alcohol, dimethicone, cetyl palmitate, myristic acid, decaglyceryl, stearyl alcohol, glucosyl hesperidin, glyceryl stearate SE, batyl alcohol, POE phytosterol, ethylhexylglycerin, sodium isostearoyl lactate, cetanol, phytosterol, hydrogenated soy phospholipid, lipophilic glyceryl stearate, acrylic acid -methacrylic acid alkyl copolymer, sodium hydroxide, purified water
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InnerSignal Rejuvenate Clear Lip

InnerSignal Rejuvenate Clear Lip

This product combines moisturizers with AMP (adenosine monophosphate), which hydrates the lips, and promotes clear lips that shine.

Are skin problems due to slow skin cell turnover?

The various skin problems such as dullness and dark spots that come with aging, as well as general dryness, are related to slow skin cell turnover. We know that this is a result of reduced energy metabolism in the skin cells.

What Is AMP?

AMP (adenosine monophosphate) is a substance produced by our bodies. The main role of AMP in the skin is to increase the energy metabolism of the mother cells deep in the skin, which promotes rejuvenation of skin cells. It is also a substance found in seeds, bulbs and tree buds, as well as in breast milk, and holds the key to energy metabolism. Based on our own research into AMP, we have developed a medicated active ingredient called, Energy Signal AMP (adenosine monophosphate OT).

Initial Effect of Skin Lightening

The skin lightening effect of Energy Signal AMP - suppressed accumulation of melanin and prevention of dark spots and freckling - was demonstrated for Rejuvenate Extract in Japan. Then, the same effect was shown for a series of other products: Rejuvenate Lotion, Rejuvenate Milk G, Rejuvenate Cream G, Rejuvenate Clear Up Mask, Rejuvenate Extract Dual, and Rejuvenate Clear Up Eyes

Ingredients
Water, glycerin, hexyldecyl isostearate, candelilla wax, mineral oil, hydrogenated jojoba oil, BG (butylene glycol), disodium adenosine phosphate, carnauba wax, glyceryl stearate, cholesteryl hydroxystearate, petroleum jelly, ascorbyl glucoside, phytosteryl oleate, sucrose stearate, PEG-30 hydrogenated castor oil, citric acid, stearyl glycyrrhetinate, dimethicone, sodium stearoyl glutamate, polyglyceryl-10 stearate, licorice flavonoid, sodium hydroxide

Resetting the skin by properly removing makeup and dirtFacial Cleansing

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InnerSignal Rejuvenate Base Soap b

InnerSignal Rejuvenate Base Soap b

This product contains AMP moisturizing formulation. Gentle to the skin, it thoroughly removes dirt while retaining moisture, leaving skin ready to receive Rejuvenate Extract. It cleanses and refreshes. Refill package also available.

Does more than just remove dirt

InnerSignal cleansing prepares the skin for the next step, Rejuvenate Extract. It is formulated with moisturizing AMP and amino acid-based cleansing ingredients that are gentle to the skin. While it cleans thoroughly, it also leaves the skin with the moisture that it needs.

Leaves the skin feeling good

Sebum and oxidized makeup grease is difficult to wash away with water, making it necessary to use a cleanser to remove them properly. InnerSignal cleanser thoroughly removes makeup and dirt, and leaves the skin feeling good. It also contains moisturizers with AMP.

Ingredients
Sodium cocoyl glycinate, microcrystalline wax, sodium stearoyl glutamate, citric acid, water, lauroyl lysine, adenosine phosphate, titanium oxide, HEDTA-3Na (hydroxyethylethylendiamintriacetic acid trisodium salt), etidronic acid, fragrance
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InnerSignal Rejuvenate Base Foam b

InnerSignal Rejuvenate Base Foam b

This product also contains AMP moisturizing formulation. It is a facial foam cleanser that prepares skin for Rejuvenate Extract. This rich base foam provides cleansing and moisture. Choose from this base foam or the refreshing base soap.

Does more than just remove dirt

InnerSignal cleansing prepares the skin for the next step, Rejuvenate Extract. It is formulated with moisturizing AMP and amino acid-based cleansing ingredients that are gentle to the skin. While it cleans thoroughly, it also leaves the skin with the moisture that it needs.

Leaves the skin feeling good

Sebum and oxidized makeup grease is difficult to wash away with water, making it necessary to use a cleanser to remove them properly. InnerSignal cleanser thoroughly removes makeup and dirt, and leaves the skin feeling good. It also contains moisturizers with AMP.

Ingredients
Water, diglycerol, sodium cocoyl glycinate, sodium cocoamphoacetate, Methyl gluceth-10, adenosine phosphate, hydroxypropyl methylcellulose, sodium lactate, etidronic acid, methylparaben, fragrance
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InnerSignal Reset Make-Off Oil b

InnerSignal Reset Make-Off Oil b

This powerful oil-based cleanser feels good on the skin. It thoroughly removes waterproof makeup while cleansing pores and clearing away sebum. It mixes easily with water and rinses quickly away, causing no burden on the skin. AMP moisturizing formulation.

Does more than just remove dirt

InnerSignal cleansing prepares the skin for the next step, Rejuvenate Extract. It is formulated with moisturizing AMP and amino acid-based cleansing ingredients that are gentle to the skin. While it cleans thoroughly, it also leaves the skin with the moisture that it needs.

Leaves the skin feeling good

Sebum and oxidized makeup grease is difficult to wash away with water, making it necessary to use a cleanser to remove them properly. InnerSignal cleanser thoroughly removes makeup and dirt, and leaves the skin feeling good. It also contains moisturizers with AMP.

Ingredients
Olive oil, mineral oil, polysorbate 85, adenosine phosphate, water, tocopherol, phenoxyethanol, fragrance
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InnerSignal Reset Make-Off Cream b

InnerSignal Reset Make-Off Cream b

This product contains AMP moisturizing formulation. Gentle to the skin, it thoroughly removes dirt while retaining moisture, leaving skin ready to receive Rejuvenate Extract. It cleanses and refreshes. Refill package also available.

Does more than just remove dirt

InnerSignal cleansing prepares the skin for the next step, Rejuvenate Extract. It is formulated with moisturizing AMP and amino acid-based cleansing ingredients that are gentle to the skin. While it cleans thoroughly, it also leaves the skin with the moisture that it needs.

Leaves the skin feeling good

Sebum and oxidized makeup grease is difficult to wash away with water, making it necessary to use a cleanser to remove them properly. InnerSignal cleanser thoroughly removes makeup and dirt, and leaves the skin feeling good. It also contains moisturizers with AMP.

Ingredients
Water, cyclopentasiloxane, olefin oligomer, ethanol, glycerin, PEG-60 hydrogenated castor oil, adenosine phosphate, carbomer, (acrylates/alkyl acrylate (C10-30)) crosspolymer, sodium acetylated hyaluronate, tremella fuciformis (snow fungus) polysaccharide, hydrolyzed collagen, BG (butylene glycol), ethylhexylglycerin, phenoxyethanol, EDTA-2Na (ethylenediaminetetraacetic acid disodium), potassium hydroxide, fragrance

Protecting the skin from daily ultraviolet damageUV Protect Makeup Base

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InnerSignal UV+IR Protect Makeup Base

InnerSignal UV+IR Protect Makeup Base

In addition to UV, this makeup base also blocks near-infrared, protecting skin from sun exposure. Superior moisture effect keeps your complexion moist and fresh. Beautiful base texture minimizes the appearance of rough skin, pores, small wrinkles and uneven coloration, promotes affinity for makeup and helps maintain a lasting finish.

Blocks UV and Near-infrared Radiation

Ultraviolet light (UV) causes changes in skin pigmentation, such as tanning or redness, which can lead to freckles or discoloration. Near-infrared radiation penetrates deeper into the skin, and is thought to affect skin condition over time. InnerSignal UV+IR Protect Makeup Base is formulated to protect your skin from both UV and near-infrared exposure.

Superior Moisture Effect

A delicate film of moisture adheres to the skin, providing even texture and coverage and long-lasting moisture. Skincare effect keeps your complexion moist and fresh beneath foundation.

Beautiful Base Finish

Moisture network mechanism ensures effortless uniform application and even texture. Smooth coverage promotes affinity for makeup and helps maintain a lasting finish. Soft focus effect minimizes the appearance of rough skin, pores, small wrinkles and uneven coloration.

Ingredients
Cyclopentasiloxane, water, zinc oxide, ethylhexyl methoxycinnamate, ethanol, (vinyl dimethicone / methicone silsesquioxane) cross-polymer, polyethylene, glycerin, PEG-9 polydimethylsiloxyethyldimethicone, inulin stearic acid, PEG-10 methicone, methicone, diethyl sebacate, pleurotus cornucopiae extract, polygonum aviculare extract, (dimethicone / PEG-10/15) cross-polymer, hydrogen dimethicone, disteardimonium hectorite, diphenylsiloxy phenyl trimethicone, trimethylsiloxysilicate, sodium chloride, (dimethicone/vinyl dimethicone) cross-polymer, aluminum hyroxide, disodium stearoyl glutamate, methyl paraben, potassium sorbate, sodium benzoate, tocopherol, butylated hydroxytoluene, titanium oxide, iron oxide

All products mentioned are sold in Japan.

Product Site of InnerSignal (Japanese)

Product Site of InnerSignal (Japanese)
Information on InnerSignal's unique AMP Skin Care System

Cosmedics

Promoting healthy skin based on Otsuka’s original ideas