• Formulated with Otsuka Pharmaceutical's medicated active ingredient Energy Signal AMP^*1, new all-in-one skin care product with time-lapse penetration combines lightening and three vital moisturizing skincare functions.
• With time-lapse penetration technology ensuring sequential penetration, a single application covers all basic skin care steps, meeting needs for simple, time saving yet effective skin care.

Otsuka Pharmaceutical Co., Ltd. (Head office: Tokyo, Japan; President: Tatsuo Higuchi) has announced the launch of InnerSignal Rejuvenate ONE, a new addition to the InnerSignal skin care system. Featuring time-lapse penetration, New InnerSignal Rejuvenate ONE is a medicated all-in-one gel-type cream that integrates lightening^*2 and three basic skin care functions of extract, lotion, and cream in a single product. InnerSignal Rejuvenate ONE will be available via the cosmedics.jp (https://cosmedics.jp/)e-commerce website from March 3, 2020.

Promotion of cellular turnover, the skin's natural cycle of renewal, is vital for maintaining beautiful, healthy skin. As we age, secretion of beneficial sebum decreases and skin loses the ability to retain moisture, leading to dryness and other conditions that are far from beneficial for our skin. In keeping with the InnerSignal concept of promoting cellular turnover to prevent formation of melanin deposits, New InnerSignal Rejuvenate ONE contains medicated active ingredient Energy Signal AMP^*1, a natural and positive approach to lightening. A single application of this all-in-one product with time-lapse penetration fulfills the three vital functions of a moisturizer - hydration to infuse the stratum corneum with moisture; softening to keep skin smooth and supple; and barrier function to seal in moisture. InnerSignal Rejuvenate ONE is a simple, one-step regimen that promotes clear, moist, and healthy skin.

This medicated all-in-one gel-type cream is recommended for women who feel pressed for time, but who still want to experience the benefits of reliable lightening and moisturizing skin care.

1. 1Disodium adenosine phosphate OT.
   This ingredient is found in InnerSignal Rejuvenate Extract, Lotion, Milk, Cream, Mask, Extract Dual, Clear Up Eyes and ONE.
2. 2Inhibits formation of melanin deposits; prevents dark spots and freckles.

Product Overview

• Official product website https://cosmedics.jp/ins/
• E-commerce website https://cosmedics.jp/

Product name (category)	InnerSignal Rejuvenate ONE (Quasi-drug)
Content	50g (approx. 1.5-month supply)
Suggested retail price	¥10,000 (plus tax)
Product characteristics	Medicated all-in-one gel-type cream Time-lapse penetration technology permits integration of extract, lotion, and cream functions into a single item. This unique all-in-one formula also combines a lightening function. Contains proprietary medicated active ingredient Energy Signal AMP to boost skin's energy metabolism and promote cellular turnover, eliminating melanin discoloration together with worn-out corneocytes, for fresh, clear skin. Combines lightening and three-step care in a single product in response to needs for simple, time saving yet effective skin care.