Otsuka Pharmaceutical Co.,Ltd.

November 18, 2021

Launch of tocoelle Supplement
- Gentle support for pre-menstrual fluctuations -

  • Available from November 18, tocoelle offers gentle support for emotional and physical fluctuations affecting approximately 80% of women.*1
  • Delivers four active components: two types of vitamin E (γ-tocopherol, γ-tocotrienol), equol, and calcium
  • One soft capsule and two soybean-shaped tablets are packaged together for daily consumption; offered in packets of seven doses as a convenient one-week supply.


Otsuka Pharmaceutical Co., Ltd. (Head office: Tokyo, Japan; President: Makoto Inoue; hereinafter Otsuka), has announced the launch of tocoelle, a supplement to support women bothered by pre-menstrual fluctuations. The new supplement will be available through medical practitioners and e-commerce sites beginning November 18, 2021.

Otsuka Pharmaceutical has pursued research related to women's health, focusing on emotional and physical fluctuations in an effort to support women to live individually, comfortably, beautifully, day-to-day. Following the introduction of the EQUELLE series of products containing soybean isoflavone metabolite equol, Otsuka has been conducting public health awareness campaigns to enhance women's health literacy. In the course of these activities, tocoelle was developed as a result of focusing on premenstrual symptoms related to women's monthly cycles. Based on scientific evidence, the combination of four active components in tocoelle offers gentle support for emotional and physical premenstrual fluctuations affecting approximately 80% of women.

Four components to alleviate emotional and physical fluctuations

  • γ-tocopherol (90mg) / γ-tocotrienol (15mg)

    Soy oil and rice oil are rich sources of these types of vitamin E. Their metabolites address the cyclical emotional and physical fluctuations that all women must face. With a mechanism that differs from standard vitamin E (α-tocopherol), these ingredients are becoming a focus of attention as support for women's health and wellbeing.

  • Equol (2mg)

    Produced when soy isoflavones are metabolized by intestinal bacteria, equol is an ingredient that supports women's health and beauty. However, among younger Japanese women, only one in five have the capacity to produce equol, even if they consume soy-based foods.*2

  • Calcium (250mg)

    Calcium, a mineral often lacking in Japanese diets, is a nutrient of particular importance for women. It is said that women in their 20s to 40s should increase daily consumption of calcium by 200mg to 250mg .*3

γ-tocopherol and γ-tocotrienol are contained in a soft capsule; equol and calcium in soybean-shaped tablets. Each daily dose of three pills is individually packaged in convenient packets of seven doses for consumption over a single week.

Origins of tocoelle product name

The tocoelle product name reflects the primary ingredient γ-tocopherol (toco) and the French word for woman (elle).

Otsuka Pharmaceutical "Elle" series


The Otsuka Pharmaceutical line of "Elle" products (EQUELLE, EQUELLE Gelée, and newly introduced tocoelle) was conceived to address health issues faced by women at various life stages.

Based on the corporate philosophy of "Otsuka-people creating new products for better health worldwide," Otsuka Pharmaceutical will continue to focus on health issues that concern women at various life stages, aiming to contribute to a society that welcomes women's energetic participation over the course of a lifetime.

  1. 1Otsuka Pharmaceutical survey of 1,000 women, aged 30 to 44; June - July 2021
  2. 2Shigeto Uchiyama: The Society of Health Care for Menopause and Aging, 7(1):26-31,2008
  3. 3National Health and Nutrition Survey; 2019

Product Overview

Official brand website: (in Japanese)

Brand name



Processed food (supplement) containing γ‐tocopherol and other components

Content 10.5g (seven packets containing one capsule / two tablets each)
Suggested retail price ¥1,200 (pre-tax)
Product characteristics
  • A supplement that delivers four important components: vitamin E (γ-tocopherol and γ-tocotrienol) contained in soy oil; equol, produced from soy isoflavones; and calcium, a mineral often lacking in daily diets.
  • A single dose (one soft capsule and two bean-shaped tablets) packaged together for portability. One packet contains seven doses for convenient one-week consumption. Consume one dose per day with cold or warm water.
  • Offered in packets of seven doses as a convenient one-week supply.
Nutrition components
1.5g (one capsule / two tablets)
Energy: 4.2kcal, protein: 0.24g, fat: 0.29g, carbohydrates: 0.27g, sodium: 0 - 0.02g, calcium: 250mg, vitamin E: 16.2mg
γ-tocopherol: 90mg, γ-tocotrienol: 15mg、S-equol: 2mg, soy isoflavones (aglycone): 1.3mg
Ingredients TABLETS: Fermented soy germ (produced in Japan) / calcium carbonate, cellulose, methylcellulose (HPMC), calcium stearate
SOFT CAPSULES: Gelatin (produced in Japan / Canada), rapeseed oil / γ-tocopherol, tocotrienol, glycerin, stabilizer (pectin)