Otsuka Pharmaceutical Co., Ltd.

November 24, 2022

New skin care brand
Introducing Sakuraé Double Action Serum
- Japan's first "double brightening" effect -

Otsuka Pharmaceutical Co., Ltd. (Otsuka) has announced the November 24, 2022 launch of Sakuraé Double Action Serum, Japan's first*1 medicated beauty extract to deliver double brightening effect*2*3. The new product will be marketed via the Otsuka "" e-commerce website (

The Sakuraé brand is the first new skin care addition to the Otsuka line of Cosmedics brands in 14 years.


Skin may be affected by discoloration, such as dark spots and freckles. Melanin is the primary cause of discoloration. Melanin plays the important role of protecting skin from ultraviolet rays, but two factors lead to discoloration. One is over-production of melanin, often due to exposure to ultraviolet rays, and the other is accumulation of melanin due to a decelerated cellular turnover.

Sakuraé Double Action Serum is a medicated beauty extract, Japan's first to offer double brightening by addressing both formation and accumulation of melanin, promoting a clear, bright complexion. Long-acting vitamin C precursor ascorbic acid 2-glucoside*2 inhibits over-production of melanin, while unique Otsuka ingredient AMP*3 promotes elimination of accumulated melanin. With continued use, the repeated Melanin Clear Cycle of 'inhibition' and 'elimination' promotes a clear, translucent complexion.

  1. *1First product in Japan to prevent dark spots and freckles by suppressing formation and accumulation of melanin
  2. *2Ascorbic acid 2-glucoside inhibits formation of melanin, prevents dark spots and freckles.
  3. *3AMP: Disodium adenosine phosphate OT suppresses accumulation of melanin, prevents dark spots and freckles

Brand Name Origin
Sakura-no-Kasane (Layered Cherry Blossoms)

Elegant 12-layered ceremonial court robes worn by Heian dynasty noblewomen were distinguished by overlapping layers of color. Named for the delicate hues of cherry blossoms, sakura-no-kasane (layered cherry blossoms) was a particularly pleasing springtime palette, characterized by an outer layer of light white silk worn over gradations of pink and red. Evoking a smooth layer of translucent skin with a slight healthy flush, we have named our new product "Sakuraé," evoking the subtle gradations of cherry blossoms.

Otsu Skin Care Research Institute (Shiga Prefecture)
Otsu Skin Care Research Institute (Shiga Prefecture)

Cosmedics*4: Otsuka's Unique Concept and Technologies Targeting Healthy Skin
Otsuka pursues business initiatives based on the corporate philosophy of creating innovative products that contribute to the health and well-being of people worldwide. Established in 1990, the Otsu Skin Care Research Institute is engaged in research and development of skin care products based on the concept of Cosmedics, focusing on healthy skin, a vital organ that accounts for approximately 16% of human body weight. Sakuraé follows Inner Signal and UL·OS as the third skin care brand to be launched from the Otsu Skin Care Research Institute.

  1. Cosmedics: cosmetics + medicine = Otsuka's unique concept for skin health products

Product Overview | Official Website:

Product name

Sakuraé Double Action Serum

Category Medicated beauty serum (Quasi-drug)
Content 33ml (approx. 1 month supply)
Suggested retail price (pre-tax/tax inclusive) ¥11,818 / ¥13,000
Product characteristics
  • Medicated beauty serum offering "double brightening effect," developed with a focus on the process from formation through elimination of melanin, the primary cause of discoloration
  • Subtle, uplifting cherry blossom fragrance
  • For use on freshly cleansed skin
  • Apply 2 to 3 drops morning and night; contains approx. 1 month supply)
Primary indications & effects Suppresses formation and accumulation of melanin, prevents dark spots and freckles
Active ingredients Disodium adenosine phosphate
Ascorbyl glucoside
Other ingredients Water, pentaerythrityl tetraethylhexanoate, glycerin, squalane, pentylene glycol, biosaccharide gum-1, tromethamine, diglycerin, methyl gluceth-10, phytosteryl isostearate, phytosteryl macadamiate, caprylic/capric/myristic/stearic triglyceride, bis-ethoxydiglycol cyclohexane 1,4- dicarboxylate, polyglycerin-3, sodium dilauramidoglutamide lysine, acrylates/C10-30 alkyl acrylate crosspolymer, 1,2-hexanediol, phenoxyethanol, pentasodium triphosphate, fragrance