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CosmedicsThe Otsuka concept of Cosmedics

The skin is the body’s largest organ.Healthy skin is beautiful skin.

Otsuka is involved in the R&D, manufacture, and sale of a range of pharmaceuticals and nutraceuticals based on its corporate philosophy of creating new products for better health worldwide. The skin is the largest organ of the human body, accounting for approximately 16% of body weight. We have a strong history of carrying out R&D in this area with unique ideas and technologies based on the concept of Cosmedics*1, focusing on skin health.

The research and development on Cosmedics began in 1990 at the Otsu Skin Care Research Institute in Shiga Prefecture, Japan. Otsuka researchers wanted to improve people’s health not only from within, but also from the outside, by ensuring the skin, the body's protective covering, was cared for. Focusing on AMP*2, a substance produced in the body, their passion and commitment bore results with the creation of a new active ingredient, Energy Signal AMP*3. Formulated based on this, Otsuka Pharmaceutical's InnerSignal product line obtained approval for novel effects and efficacy and was launched in 2005*4.

UL・OS, launched in 2008, was also formulated using the moisturizing ingredient AMP*5, based on Otsuka's unique formula. Focusing on skin health for middle-aged men, the UL・OS line has steadily expanded to include moisturizer, sunblock, skin wash, refresh sheets, shampoo and whitening care*6. UL・OS has grown into a brand that offers total skin care for the body from head to toe.

In 2012, marketing of UL・OS began in South Korea, the first market outside Japan for Cosmedics. Going forwards, we will expand our business both in Japan and globally based on the Cosmedics concept.

  1. 1Cosmedics: cosmetics + medicine
  2. 2Generic term for adenosine monophosphate
  3. 3Disodium adenosine phosphate OT
  4. 4Suppresses accumulation of melanin and prevents skin blemishes and freckles
  5. 5Adenosine monophosphate
  6. 6Suppresses production of melanin and prevents skin blemishes and freckles


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