Living well with menopause

Research on equol

There has been a variety of studies on how equol works, and its effects on the human body. More recently, it has been shown to have a broad effect on maintaining the overall health in women over 40, such as ameliorating the effects of menopause and maintaining the health of bones, the skin, and blood vessels.

  1. 1The cross-sectional study of the relationship between soy isoflavones, equol and the menopausal symptoms in Japanese women [in Japanese]
    Uchiyama S, Ueno T, Masaki K, Shimizu S, Aso T, Shirota T (2007)
    J Jpn Menopause Soc; 15, 28-37
  2. 2Identification of a Newly Isolated Equol-Producing Lactic Acid Bacterium from the Human Feces [in Japanese]
    Uchiyama S, Ueno T, Suzuki T (2007)
    J Intest Microbiol; 21, 217-220
  3. 3Detection of Lactococcus garvieae in Foods and its Existence in the Human Intestine [in Japanese]
    Uchiyama S, Kimura H, Ueno T, Suzuki T, Tadano K, Ishimi Y (2007)
    J Intest Microbiol; 21, 221-225
  4. 4Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial
    Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y (2007)
    Menopause; 14, 866-874
  5. 5Acute and subchronic toxicity, and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieae
    Yee S, Burdock GA, Kurata Y, Enomoto Y, Narumi K, Hamada S, Itoh T, Shimomura Y, Ueno T (2008)
    Food and Chemical Toxicology; 46, 2713-2720
  6. 6Developmental and Reproductive Effects of SE5-OH: An Equol-Rich Soy-Based Ingredient
    Matulka RA, Matsuura I, Uesugi T, Ueno T, Burdock GA (2009)
    J Toxicol; ID 307618, [Epub 15 December 2008]
  7. 7The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women
    Setchell KDR, Zhao X, Shoaf SE, Ragland K (2009)
    J Nutr; 139, 2037-2043
  8. 8Equol improves menopausal symptoms in Japanese women
    Aso T (2010)
    J Nutr; 140, 1386S-1389S.
  9. 9Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial
    Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y (2011)
    Menopause; 18, 563-574
  10. 10Effects of S-equol and natural S-equal supplement (SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice
    Onoda A, Ueno T, Uchiyama S, Hayashi S, Kato K, Wake N (2011)
    Food Chem Toxicol; 49, 2279-2284
  11. 11The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial
    Oyama A, Ueno T, Uchiyama S, Aihara T, Miyake A, Kondo S, Matsunaga K (2012)
    Menopause; 19, 202-210
  12. 12A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women
    Aso T, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H (2012)
    J Womens Health (Larchmt); 21, 92-100
  13. 13A pilot study on the effects of S-equol compared to soy isoflabones on menopausal hot flash frequency
    Jenks B, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson W, Ueno T, Uchiyama S (2012)
    J Womens Health (Larchmt); 21, 674-682
  14. 14Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status
    Usui T, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A, Shimatsu A, Inaguma A, Ueno T, Uchiyama S, Satoh-Asahara N (2013)
    Clin Endocrinology; 78, 365-372
  15. 15Discovery of an S-equol rich food stinky tofu, a traditional fermented soy product in Taiwan
    AbiruY, Kumemura M, Ueno T, Uchiyama S, Masaki K (2012)
    Int J Food Sci Nutr; 63, 964-970
  16. 16Distribution of 24-h urinary equol excretion as an indicator of the physiological range in healthy Japanese equol excretors
    Ueno T, Abiru Y, Uchiyama S, Ishimi Y (2014)
    J Functional Foods; 7, 129-135