InnerSignal
Unique Skin Care System Based on Otsuka’s Concern for Skin Health
The key to the InnerSignal skin care system is Energy Signal AMP*, a medicated active ingredient that promotes cellular turnover. It works by boosting the energy metabolism of skin cells that have been negatively impacted by factors such as lifestyle habits and aging, and by encouraging skin rejuvenation.
Skin that’s constantly rejuvenated
Why doesn’t our skin look the same as when we were in our 20s?
As we age, cellular turnover – the skin’s power to rejuvenate itself – decelerates, leading to problems such as discoloration, dullness, and dryness.
At Otsuka Pharmaceutical, we focused on the energy metabolism of metrocytes, also known as “mother cells.”
Extensive research led to the development of Energy Signal AMP*, a unique medicated active ingredient that promotes cellular turnover by boosting the energy metabolism of metrocytes deep within the layers of the skin, generating additional energy required for the production of new skin cells. As metrocytes produce new skin cells, cellular turnover is invigorated, flooding the outer layers of the skin with fresh cells and promoting a healthy, smooth translucent complexion.
- *Disodium adenosine phosphate OT : This ingredient is found in InnerSignal Rejuvenate Extract, Lotion, Milk, Cream, Mask, Extract Dual, Clear Up Eyes, and ONE.
Product Line-up
InnerSignal Rejuvenate Extract
Quasi-drug
This extract quickly delivers Energy Signal AMP, InnerSignal's unique active medical ingredient, to the skin's mother cells. This increases their energy metabolism and promotes cell turnover, for newer and clearer skin.
| Active ingredients | DISODIUM ADENOSINE PHOSPHATE, DIPOTASSIUM GLYCYRRHIZATE |
|---|---|
| Other ingredients | GLYCERIN, SQUALANE, POLYGLYCERYL-10 ISOSTEARATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, SODIUM ISOSTEAROYL LACTATE, POLYGLYCERYL-10 STEARATE, ALCOHOL, METHYLPARABEN, BUTYLPARABEN, SODIUM HYDROXIDE, WATER |
InnerSignal Rejuvenate ONE
Quasi-drug
Medicated active ingredient Energy Signal AMP boosts skin’s energy metabolism to promote cellular turnover, eliminating melanin – the source of discoloration – together with worn-out corneocytes, for fresh, clear skin. With a single application, moisture and emollients penetrate the skin’s corneal layer, providing ideal levels of moisture. When used together with InnerSignal Rejuvenate Extract, skin is supported with beautifying ingredients, affording ideal, effective daily skin care.
| Active ingredients | DISODIUM ADENOSINE PHOSPHATE |
|---|---|
| Other ingredients | WATER, PENTAERYTHRITYL TETRAETHYLHEXANOATE, SQUALANE, PENTYLENE GLYCOL, GLYCERIN, DIGLYCERIN, BIOSACCHARIDE GUM-1, METHYL GLUCETH-10, PHYTOSTERYL/BEHENYL/OCTYLDODECYL LAUROYL GLUTAMATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, CARBOMER, CAPRYLIC/CAPRIC/MYRISTIC/STEARIC TRIGLYCERIDE, STEAROYL INULIN, HYDROLYZED COLLAGEN, SODIUM HYALURONATE, HYDROLYZED HYALURONIC ACID, ANANAS SATIVUS (PINEAPPLE) FRUIT EXTRACT, BETAINE, SODIUM PCA, PCA, SODIUM HYDROXIDE, SODIUM LACTATE, PCA, SERINE, ALANINE, GLYCINE, GLUTAMIC ACID, LYSINE HCL, THREONINE, ARGININE, PROLINE, TOCOPHEROL, 1,2-HEXANEDIOL, PHENOXYETHANOL, TROMETHAMINE, DISODIUM EDTA, FRAGRANCE |
InnerSignal Rejuvenate Lotion
Quasi-drug
This lotion contains nine types of moisturizing ingredients including hyaluronic acid, and penetrating glucose, as well as Energy Signal AMP, the medicated active ingredient. Along with accentuating the effect of the AMP, this lotion leaves every inch of the outer epidermis full of moisture.
| Active ingredient | DISODIUM ADENOSINE PHOSPHATE |
|---|---|
| Other ingredients | ROSA CENTIFOLIA FLOWER WATER, GLYCERIN, METHYL GLUCETH-20, PEG-6, PEG-32, GLYCOSYL TREHALOSE, HYDROGENATED STARCH HYDROLYSATE, PPG-6-DECYLTETRADECETH-30, POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE, XANTHAN GUM, SODIUM HYALURONATE, GLUCOSE, SQUALANE, HYDROGENATED LECITHIN, POLYGLYCERYL-10 LAURATE, PENTYLENE GLYCOL, TOCOPHEROL, ALCOHOL, METHYLPARABEN, MALIC ACID, SODIUM HYDROXIDE, WATER |
InnerSignal Repair Lotion
Quasi-drug
A moisturizing lotion with a fresh feel.
It is formulated with the active ingredient dipotassium glycyrrhizate to prevent rough skin and enriched with the moisturizing ingredient ectoine to leave skin looking bright and clear.
| Active ingredient | DIPOTASSIUM GLYCYRRHIZATE |
|---|---|
| Other ingredients | WATER, ROSA CENTIFOLIA FLOWER WATER, GLYCERIN, BUTYLENE GLYCOL, PENTYLENE GLYCOL, OCTYLDODECYL MYRISTATE, PPG-9 DIGLYCERYL ETHER, PPG-6-DECYLTETRADECETH-20, METHYLPARABEN, PHENOXYETHANOL, PHYTOSTERYL ISOSTEARATE, SODIUM CITRATE, GLYCOSYL TREHALOSE, HYDROGENATED LECITHIN, XANTHAN GUM, HYDROGENATED STARCH HYDROLYSATE, ECTOIN, DISODIUM EDTA, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, CITRIC ACID, PHYTOSTEROLS, BIOSACCHARIDE GUM-1, POTASSIUM HYDROXIDE, POLYQUATERNIUM-51, TAMARINDUS INDICA SEED GUM, PECTIN, HYDROXYPROPYLTRIMONIUM HYALURONATE |
InnerSignal Rejuvenate Milk G
Quasi-drug
This product contains the medicated active ingredient Energy Signal AMP as well as penetrating glucose and natural ceramide as moisturizing ingredients. It adequately replenishes AMP in the skin, and leaves it plump and supple.
| Active ingredient | DISODIUM ADENOSINE PHOSPHATE |
|---|---|
| Other ingredients | GLYCERIN, HYDROGENATED POLY(C6-12 OLEFIN), ALCOHOL, ROSA CENTIFOLIA FLOWER WATER, POLYGLYCERYL-10 ISOSTEARATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, SODIUM ISOSTEAROYL LACTATE, POLYGLYCERYL-10 STEARATE, BUTYLENE GLYCOL, POLYGLYCERYL-10 MYRISTATE, CERAMIDE NG, CHOLESTEROL, PHENOXYETHANOL, TOCOPHEROL, GLUCOSE, SQUALANE, HYDROGENATED LECITHIN, POLYGLYCERYL-10 LAURATE, PENTYLENE GLYCOL, METHYLPARABEN, BUTYLPARABEN, SODIUM HYDROXIDE, WATER |
InnerSignal Repair Milk
Quasi-drug
A high moisturizing milk with a rich texture.
It is formulated with the active ingredient stearyl glycyrrhetinate to prevent rough skin and enriched with moisturizing ingredients mevalonolactone, ceramide*, and sodium hyaluronate to leave skin soft, hydrated, and beautiful.
* Ceramide2
| Active ingredient | STEARYL GLYCYRRHETINATE |
|---|---|
| Other ingredients | WATER, GLYCERIN, BUTYLENE GLYCOL, DIETHYL SEBACATE, PENTAERYTHRITYL TETRAETHYLHEXANOATE, TRIETHYLHEXANOIN, PENTYLENE GLYCOL, CAPRYLIC/CAPRIC/MYRISTIC/STEARIC TRIGLYCERIDE, GLYCERYL GLUCOSIDE, DIGLYCERIN, DIMETHICONE, GLYCERYL STEARATE, POLYGLYCERIN-3, BEESWAX, PHYTOSTERYL/OCTYLDODECYL LAUROYL GLUTAMATE, GLYCOSYL TREHALOSE, HYDROGENATED LECITHIN, GLYCERYL BEHENATE, POLYGLYCERYL-6 OCTASTEARATE, HYDROGENATED STARCH HYDROLYSATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, PHENOXYETHANOL, TOCOPHEROL, METHYLPARABEN, POLYGLYCERYL-10 LAURATE, POTASSIUM HYDROXIDE, FRAGRANCE, PHYTOSTEROLS, DISODIUM EDTA, SODIUM HYALURONATE, XANTHAN GUM, MEVALONOLACTONE, POLYGLYCERYL-10 MYRISTATE, CERAMIDE NG, CHOLESTEROL |
InnerSignal SC Rich Cream
Rich-textured, highly moisturizing skin care cream.
Containing stratum corneum-smoothing ingredient gluconolactone*, this highly moisturizing, weakly acidic skin cream moisturizes and softens stratum corneum to promote supple, healthy skin.
White rose fragrance.
* Moisturizer
| Ingredients |
|---|
| WATER, DIISOSTEARYL MALATE, BUTYLENE GLYCOL, DIMETHICONE, GLYCERIN, CAPRYLIC/CAPRIC/MYRISTIC/STEARIC TRIGLYCERIDE, SQUALANE, PENTAERYTHRITYL TETRAETHYLHEXANOATE, CETYL ETHYLHEXANOATE, PPG-9 DIGLYCERYL ETHER, PENTYLENE GLYCOL, BIS-ETHOXYDIGLYCOL CYCLOHEXANE 1,4-DICARBOXYLATE, PHYTOSTERYL MACADAMIATE, TRIPROPYLENE GLYCOL, HYDROGENATED LECITHIN, STEARETH-2, STEARETH-21, DIGLYCERIN, BEHENYL ALCOHOL, PHYTOSTERYL/BEHENYL/OCTYLDODECYL LAUROYL GLUTAMATE, MICROCRYSTALLINE WAX, TREMELLA FUCIFORMIS POLYSACCHARIDE, SODIUM HYALURONATE, GLUCONOLACTONE, BIOSACCHARIDE GUM-1, GLYCOSYL TREHALOSE, TOCOPHEROL, PHYTOSTEROLS, POLYGLYCERYL-10 DECAISOSTEARATE, GLYCERYL BEHENATE, POLYGLYCERYL-6 OCTASTEARATE, HYDROGENATED STARCH HYDROLYSATE, PEG-150 DISTEARATE, SCLEROTIUM GUM, XANTHAN GUM, ACACIA SENEGAL GUM, SODIUM POLYACRYLATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER, POLYQUATERNIUM-61, DECYLTETRADECANOL, DIPHENYLSILOXY PHENYL TRIMETHICONE, CYCLOPENTASILOXANE, ISOSTEARYL SEBACATE, DISODIUM STEAROYL GLUTAMATE, ALUMINUM HYDROXIDE, PHENOXYETHANOL, SODIUM GLUCONATE, DISODIUM EDTA, IRON OXIDES（Cl No. 77492）, FRAGRANCE |
InnerSignal Rejuvenate Clear Up Eyes
(Initial product name: InnerSignal Medicated Cream)
Quasi-drug
This product is for multiple problems under the eyes, which are always a concern. The medicated active ingredient, Energy Signal AMP, increases the energy metabolism of skin cells, helping to promote eyes that are firm, clear and fresh. At the same time, it supplies a moisturizing effect from multiple ingredients such as hydrogenated soybean phospholipids, batyl alcohol, and glucosyl hesperidin, which strengthen the skin's barrier and moisturizing functions.
| Active ingredient | DISODIUM ADENOSINE PHOSPHATE |
|---|---|
| Other ingredients | HYDROGENATED POLY(C6-12 OLEFIN), GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, BEHENYL ALCOHOL, DIMETHICONE, CETYL PALMITATE, POLYGLYCERYL-10 MYRISTATE, STEARYL ALCOHOL, GLUCOSYL HESPERIDIN, GLYCERYL STEARATE, PEG-100 STEARATE, BATYL ALCOHOL, PEG-20 PHYTOSTEROL, ETHYLHEXYLGLYCERIN, SODIUM ISOSTEAROYL LACTATE, CETYL ALCOHOL, PHYTOSTEROLS, HYDROGENATED LECITHIN, GLYCERYL STEARATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, SODIUM HYDROXIDE, WATER |
InnerSignal Clear Lip
Containing moisturizing ingredient AMP (disodium adenosine phosphate), this product hydrates and promotes lips that are smooth and moist.
| Ingredients |
|---|
| MINERAL OIL, PARAFFIN, DIISOSTEARYL MALATE, POLYBUTENE, GLYCERIN, WATER, PETROLATUM, DIPENTAERYTHRITYL HEXAHYDROXYSTEARATE/HEXASTEARATE/HEXAROSINATE, DIPHENYLSILOXY PHENYL TRIMETHICONE, SQUALANE, DISODIUM ADENOSINE PHOSPHATE, PHYTOSTERYL/OCTYLDODECYL LAUROYL GLUTAMATE, MICROCRYSTALLINE WAX, POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE, BUTYLENE GLYCOL,SYNTHETIC WAX, POLYGLYCERYL-6 POLYRICINOLEATE, DIPALMITOYL HYDROXYPROLINE, VINYL DIMETHICONE/LAURYL DIMETHICONE CROSSPOLYMER, LAURYL DIMETHICONE/POLYGLYCERIN-3 CROSSPOLYMER, SODIUM CHLORIDE, POLYGLYCERYL-2 ISOSTEARATE, DISTEARDIMONIUM HECTORITE, PENTYLENE GLYCOL, STEARYL GLYCYRRHETINATE, TOCOPHEROL, CETEARYL ETHYLHEXANOATE, SORBITAN ISOSTEARATE, PORTULACA PILOSA EXTRACT, SUCROSE COCOATE, PALMITOYL TRIPEPTIDE-38 |
InnerSignal Rejuvenate Clear Up Mask
(Initial product name: InnerSignal Rejuvenate Clear Up Mask F)
Quasi-drug
Focused delivery of Energy Signal AMP boosts the energy metabolism of metrocytes (mother cells) to promote enhanced resilience and translucence. Use once a week as an extension of your home beauty routine.
| Active ingredient | DISODIUM ADENOSINE PHOSPHATE |
|---|---|
| Other ingredients | DIPROPYLENE GLYCOL, SQUALANE, GLYCERIN, POLYGLYCERYL-10 ISOSTEARATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, SODIUM ISOSTEAROYL LACTATE, POLYGLYCERYL-10 STEARATE, METHYLPARABEN, BUTYLPARABEN, SODIUM HYDROXIDE, WATER |
InnerSignal Cleansing Oil
This powerful oil-based cleanser feels good on the skin. It thoroughly removes waterproof makeup while cleansing pores and clearing away sebum. It mixes easily with water and rinses quickly away, causing no burden on the skin.
| Ingredients |
|---|
| MINERAL OIL, ETHYLHEXYL PALMITATE, HYDROGENATED POLYISOBUTENE, PEG-8 GLYCERYL ISOSTEARATE, PEG-10 GLYCERYL DIISOSTEARATE, PHENYL TRIMETHICONE, WATER, BHT, FRAGRANCE |
InnerSignal Cleansing Cream
Gentle to the skin, this cleansing cream thoroughly removes dirt while retaining moisture, leaving skin ready to receive Rejuvenate Extract. It cleanses and refreshes. Refill package also available.
| Ingredients |
|---|
| WATER, MINERAL OIL, BUTYLENE GLYCOL, PEG-7 GLYCERYL COCOATE, XANTHAN GUM, SODIUM POLYACRYLATE, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, PHENOXYETHANOL, METHYLPARABEN, PROPYLPARABEN, POTASSIUM HYDROXIDE, ETIDRONIC ACID, BHT, FRAGRANCE |
InnerSignal Rejuvenate Base Soap b
This product contains AMP moisturizing formulation. Gentle to the skin, it thoroughly removes dirt while retaining moisture, leaving skin ready to receive Rejuvenate Extract. It cleanses and refreshes. Refill package also available.
| Ingredients |
|---|
| SODIUM COCOYL GLYCINATE, MICROCRYSTALLINE WAX, SODIUM STEAROYL GLUTAMATE, CITRIC ACID, WATER, LAUROYL LYSINE, ADENOSINE PHOSPHATE, TITANIUM DIOXIDE, TRISODIUM HEDTA, ETIDRONIC ACID, FRAGRANCE |
InnerSignal Rejuvenate Base Foam b
This product also contains AMP moisturizing formulation. It is a facial foam cleanser that prepares skin for Rejuvenate Extract. This rich base foam provides cleansing and moisture. Choose from this base foam or the refreshing base soap.
| Ingredients |
|---|
| WATER, DIPROPYLENE GLYCOL, POTASSIUM COCOYL GLYCINATE, SODIUM COCOAMPHOACETATE, GLYCERIN, SODIUM COCOYL ISETHIONATE, PEG-2 CAPRYLYLAMINE, ADENOSINE PHOSPHATE, POLYQUATERNIUM-7, ACACIA SENEGAL GUM, CITRIC ACID, METHYLPARABEN, PROPYLPARABEN, PHENOXYETHANOL, DISODIUM EDTA, FRAGRANCE |
InnerSignal UV+IR Protect Base
Double protection from both UV and near-infrared exposure.
Makeup base creates a bright and radiant finish.
| Ingredients |
|---|
| CYCLOPENTASILOXANE, WATER, ZINC OXIDE, ETHYLHEXYL METHOXYCINNAMATE, ALCOHOL, VINYL DIMETHICONE/METHICONE SILSESQUIOXANE CROSSPOLYMER, POLYETHYLENE, GLYCERIN, PEG-9 POLYDIMETHYLSILOXYETHYL DIMETHICONE, STEAROYL INULIN, PEG-10 DIMETHICONE, DIMETHICONE, BUTYLENE GLYCOL, DIETHYL SEBACATE, PLEUROTUS CORNUCOPIAE EXTRACT, POLYGONUM AVICULARE EXTRACT, DIMETHICONE/PEG-10/15 CROSSPOLYMER, HYDROGEN DIMETHICONE, DISTEARDIMONIUM HECTORITE, DIPHENYLSILOXY PHENYL TRIMETHICONE, TRIMETHYLSILOXYSILICATE, SODIUM CHLORIDE, DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER, ALUMINUM HYDROXIDE, DISODIUM STEAROYL GLUTAMATE, METHYLPARABEN, POTASSIUM SORBATE, SODIUM BENZOATE, TOCOPHEROL, BHT, TITANIUM DIOXIDE, IRON OXIDES |
All products mentioned are sold in Japan.
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